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Effects of Coriolus versicolor polysaccharides on
superoxide dismutase activities in mice.
Wei WS, Tan JQ, Guo F, Ghen HS, Zhou ZY, Zhang ZH, Gui L
Department of Pharmacology, Second Military Medical University, Shanghai, China.
Chung Kuo Yao Li Hsueh Pao 1996 Mar;17(2):174-8
AIM: To study if Coriolus versicolor polysaccharides (CVP) influence the
superoxide dismutase (SOD) activities in mice. METHODS: Normal, tumor-bearing,
and radiated ICR mice were injected ip with CVP daily for 3-15 d. The SOD
activity was assayed by epinephrine autoxidation test. RESULTS: The SOD
activities in lymphocytes and thymus were increased by CVP in both the normal
mice with or without delayed hypersensitivity (DH). In tumor-bearing mice, CVP
exerted not only inhibitory effects on tumor, growth and SOD activity in tumor
tissue but also complete or partial restorative effects on the suppressed DH and
on the declined SOD activities in lymphocytes, spleen, and thymus. The total SOD
and manganese-containing SOD (MnSOD) activities in lymphocytes and thymus were
dose-dependently enhanced by CVP (5-20 mg.kg-1) on d 3 after the tumor
transplantation. In the mice exposed to 60Co (3 or 6 Gy), DH and SOD activities
were dose-dependently decreased. These changes were completely or partly
prevented by CVP. CONCLUSION: CVP exerted the favorable effects on SOD
activities in mice. Coriolus versicolor polysaccharides (CVP) exert inhibitory
effects on experimental and clinical tumors. These effects are presumed to be
mediated mainly by host-defence mechanism, especially immunological responeses.
Superoxide dismutase (SOD) plays an important role in protecting cells against
superoxide radical (O2-.) damages and over-production of O2-. or SOD abnormities
exist in many diseases. The present study was to investigate if the CVP could
exert some favorable effects on SOD activities in vivo.
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