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Life Sci 1997;60(25):PL383-PL387
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Polysaccharopeptide from Coriolus versicolor
has potential for use against human immunodeficiency virus type
I (HIV-1) infection. |
Collins RA, Ng TB
Department of Biochemistry, The Chinese
University of Hong Kong, Shatin, New Territories
| Polysaccharopeptide (PSP) isolated from the edible mushroom
Coriolus versicolor was tested for its potential as an anti-human
immunodeficiency virus type 1 (HIV-1) compound in a series of in
vitro assays. It demonstrated inhibition of the interaction
between HIV-l gp 120 and immobilized CD4 receptor (1C50 = 150 microg/ml), potent inhibition of
recombinant HIV-1 reverse transcriptase (1C50 = 6.25 microg/ml), and inhibited a glycohydrolase enzyme associated with
viral glycosylation. These properties, coupled with its high
solubility in water, heat-stability and low cytotoxicity, make it
a useful compound for further studies on its possible use as an
anti-viral agent in vivo. |
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