|
| |
Gen Pharmacol 1997 Aug;29(2):269~273
|
Polysaccharopeptide from the mushroom
Coriolus versicolor possesses analgesic activity but does not
produce adverse effects on female reproductive or embryonic
development in mice.
|
Ng TB, Chan WY
Departments of Biochemistry and
Anatomy, Faculty of Medicine, Chinese University of Hong Kong,
Shatin, N.T., Hong Kong.
| 1. Coriolus versicolor polysaccharopeptide has
been reported to exert immunomodulatory and antitumor actions.
The present study showed that it exhibits analgesic activity in
the hot-plate test upon intraperitoneal administration to ICR
mice. 2. It did not affect ovarian steroidogenesis, ovulation and
midterm gestation in mice. It did not exert an adverse effect on
mouse embryonic development either, as evidenced by the lack of
an effect on somite number, axial length and the incidence of
abnormalities in heartbeat, yolk sac circulation, optic vesicle,
otic vesicle, shape of body axis, forelimb buds, branchial
apparatus, cranial neural tube and head size. 3. Its analgesic
activity would add to its attribute as an immunomodulatory and
antitumor drug. |
Home Page Go
to Science documents page
Next Page
|
