Coriolus versicolor
PSP- Classic
Cordyceps sinensis
Cordyceps- Classic
Cordyceps- Mama
Cordyceps- Baba
Ganoderma lucidum
Dr.Xi' formulas
Dr.Xi'sBlend #1
Dr.Xi'sBlend #2
Dr.Xi'sBlend #3
Chronic fatigue
G-I patches
To Order
Contact us


Cordyceps sinensis (Berk.) Sacc.   We use Paecilomyces hepiali  Cs-4

Cordyceps sinensis is one of the most valued medicinal fungi in all of Chinese medicine and among the most potent. In Chinese it is called "Winter warm summer grass" . Cordyceps mushroom is also known as "Caterpillar mushroom". It is  naturally found in  the highlands of China, Tibet and Nepal above 10,000 feet. In early spring when the snow is just melting, people crawl on the ground to search for the smaller than finger size mushroom. Its price is more than its weight in gold.

 In this modern scientific time, we are able to culture it for higher and purer harvest.  Cordyceps has been traditionally used in China to include the relief of bronchial inflammation; treatment of chronic bronchitis; insomnia, hypertension, pneumonia; pulmonary emphysema and tuberculosis; relief of exhaustion or tiredness; debility following illness; anemia; night sweats and cough.  Cordyceps has properties similar to ginseng, being used to strengthen and rebuild the body after exhaustion. It is highly regarded for restoring vitality.

Cordyceps recently caught public attention in 1993 when a group of  previously mediocre Chinese runners proceeded to break nine world records in World Outdoor Track and Field Championships in Germany. Afterwards the coach attributed the results to the use of Cordyceps based tonic.

Research has indicated that this mushroom enhances oxygen uptake by the brain and heart while improving resistance to hypoxia. It helps building up the endurance of athletes.


Cordyceps sinensis (C. Sinensis), a major parasitic fungus, grows on the larvae of Lepidoptera (Mains, 1958; McEwen, 1963, Kabahasi, 1941) It is one of the best known fungi used in traditional medicine in China (Shimitsu, 1978).

Various bioactive components are contained in fungi of the genus Cordyceps. In 1950, the nucleoside derivative-cordycepin was isolated from C. Militaris by Cuningham et al. (Cuningham et al., 1950, Kredich and Guarino, 1961).

Cordyceps contains all types of nucleosides used in gene regeneration or repairs.   DNA & RNA are formed by long chains of  polynucleotides, which are composed of millions of nucleosides. Therefore the effect of supplying  "ready to use building blocks" is absolutely vital.

Reported biological activities of cordycepin include:

  • (a) Inhibits the production of  DNA and RNA synthesis in cancer cells. (Plageman and Erabe, 1971);
  • (b) enhancement of cell differentiation (Mathew et al., 1989);
  • (c) restructuring of cytoskeleton in cells (Deitchand, 1979, Zieve and Roemer, 1988);
  • (d) inhibition of protein kinase activity (Glazer and Juo, 1977);
  • (e) antitumor activity on bladder, kidney, colon, lung carcinoma as well as fibroblastoma (Hubell et al., 1985);
  • (f) inhibition of the infection and reverse transcriptase activity of human immunodeficiency virus type I (Montefiori et al., 1989; Muller et al., 1991)
  • (g) inhibition of methylation of nucleic acid (Noval-fernandez and Leory, 1980); and
  • (h) inhibition of chemotaxis and specific proteins synthesis of the macrophage cell line (Aksamit et al., 1983).

In 1983, galactomannan, a polysaccharide isolated from C. cicadae was shown to prevent the growth of Sarcoma 180 in mice (Ukai et al., 1983).

In addition, polysaccharides purified from Cordyceps ophiglossoides have been reported as antitumor agents (Ohmari et al., 1986, Yanada, 1984).

Thus, it is suggested that Cordyceps sp. exhibits antitumor, antiviral, and many other biological activities. Y.C. Kuo, W.J. Tsai, M-S. Shia., C-F Chen and C-Y Lin, Cordyceps sinensis as an Immunomodulatory Agent, American Journal of Chinese Medicine, Vol. XXIV, No. 2, pp.111-125.

Effects of a water-soluble extract of Cordyceps sinensis on steroidogenesis and capsular morphology of lipid droplets in cultured rat adrenocortical cells. Cordyceps sinensis contains a factor that stimulates corticosteroid production in the animal model. However, it is not known whether this drug acts directly on the adrenal glands or indirectly via the hypothalamus-pituitary axis. In the present study, we used primary rat adrenal cell cultures to investigate the pharmacological function of a water-soluble extract of Cordyceps sinensis (CS) and the signaling pathway involved. Radio immunoassay of corticosterone indicated that the amount of corticosterone produced by adrenal cells is increased in a positively dose-dependent manner by CS, reaching a maximum at 25 microgram/ml. This stimulating effect was seen 1 h after CS treatment and was maintained for up to 24 h. Concomitantly, the lipid droplets in these cells became small and fewer in number. Immunostaining with a monoclonal antibody, A2, a specific marker for the lipid droplet capsule, demonstrated that detachment of the capsule from the lipid droplet occurs in response to CS application and that the period required for decapsulation is inversely related to the concentration of CS applied. The mechanism of CS-induced steroidogenesis is apparently different from that for ACTH, since intracellular cAMP levels were not increased in CS-treated cells. However, combined application with calphostin C, a PKC inhibitor, completely blocked the effect of CS on steroidogenesis, suggesting that activation of PKC may be responsible for the CS-induced steroidogenesis.,Wang SM; Lee LJ; Lin WW; Chang CM , Department of Anatomy, College of Medicine, National Taiwan University, Taipei, Republic of China, J Cell Biochem, 69(4):483-9 1998 Jun 15

Effect of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells., Cordyceps sinensis is a herb medicine with antitumor activity capable of suppressing the growth of mouse Sarcoma 180 in vivo. In the present study, we have isolated polysaccharide fraction of Cordyceps sinensis (PSCS) and investigated its effect on the proliferation and differentiation of human leukemic U937 cells using an in vitro culture system. Our results showed that the conditioned medium from PSCS (10 microg/ml)-stimulated blood mononuclear cells (PSCS-MNC-CM) had an activity that could significantly inhibit the proliferation of U937 cells resulting in a growth inhibition rate of 78-83%. Furthermore, PSCS-MNC-CM treatment induced about 50% of the cells differentiating into mature monocytes/macrophages expressing nonspecific esterase (NSE) activity and the surface antigens of CD11b, CD14, and CD 68. Yet, the differentiated U937 cells also had functions of phagocytosis and superoxide production. However, PSCS alone or normal MNC-CM had no such effects. The levels of interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-1 were very low in normal MNC-CM, and they were greatly increased in MNC-CM prepared with PSCS stimulation. Antibody neutralization studies further revealed that the tumoricidal and differentiating effects of PSCS-MNC-CM were mainly derived from the elevated cytokines, especially IFN-gamma and TNF-alpha. These two cytokines acted synergistically on inhibiting cell growth and inducing differentiation of the target U937 cells. ,Chen YJ; Shiao MS; Lee SS; Wang SY , Department of Medical Research, Veterans General Hospital-Taipei, Taiwan, Republic of China. ,Life Sci, 60(25):2349-59 1997

Cordyceps sinensis as an immunomodulatory agent., Effects of various fractions of methanol extracts from fruiting bodies of Cordyceps sinensis on the lymphoproliferative response, natural killer (NK) cell activity, and phytohemagglutinin (PHA) stimulated interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) production on human mononuclear cells (HMNC) were studied. Two of the 15 column fractions (CS-36-39 and CS-48-51) significantly inhibited the blastogenesis response (IC50 = 71.0 +/- 3.0 and 21.7 +/- 2.0 micrograms/ml, respectively), NK cell activity (IC50 = 25.0 +/- 2.5 and 12.9 +/- 5.8 micrograms/ml, respectively) and IL-2 production of HMNC stimulated by PHA (IC50 = 9.6 +/- 2.3 and 5.5 +/- 1.6 micrograms/ml, respectively). TNF-alpha production in HMNC cultures was also blocked by CS-36-39 and CS-48-51 (IC50 = 2.7 +/- 1.0 and 12.5 +/- 3.8 micrograms/ml, respectively). These results indicated that neither CS-36-39 nor CS-48-51 was cytotoxic on HMNC, and that immunosuppressive ingredients are contained in Cordyceps sinensis., Kuo YC; Tsai WJ; Shiao MS; Chen CF; Lin CY , National Research Institute of Chinese Medicine, Veterans General Hospital, Taipei, Taiwan. ,Am J Chin Med, 24(2):111-25 1996 .

Polysaccharides in fungi. XXXVI. Hypoglycemic activity of a polysaccharide (CS-F30) from the cultural mycelium of Cordyceps sinensis and its effect on glucose metabolism in mouse liver. , A polysaccharide (CS-F30) obtained from the cultural mycelium of Cordyceps sinensis showed potent hypoglycemic activity in genetic diabetic mice after intraperitoneal administration, and the plasma glucose level was quickly reduced in normal and streptozotocin-induced diabetic mice after intravenous administration. Administration of CS-F-30 to normal mice significantly increased the activities of hepatic glucokinase, hexokinase and glucose-6-phosphate dehydrogenase, although the glycogen content in the liver was reduced. Furthermore, CS-F30 lowered the plasma triglyceride level and cholesterol level in mice. , Kiho T; Yamane A; Hui J; Usui S; Ukai S ,Gifu Pharmaceutical University, Japan. ,Biol Pharm Bull, 19(2):294-6 1996 Feb .

Effects of the mycelial extract of cultured Cordyceps sinensis on in vivo hepatic energy metabolism in the mouse. , Mice were given the extract of cultured Cordyceps sinensis (Cs) (200 mg/kg daily, p.o.) for 3 weeks. In vivo phosphorus-31 nuclear magnetic resonance (NMR) spectra of the liver were acquired at weekly intervals using a surface coil. From 1 to 3 weeks, a consistent increase in the ATP/inorganic phosphate ratio, which represents the high energy state, was observed in the Cs extract-treated mice. The intracellular pH of the Cs extract-treated mice was not significantly different from that of the control mice. No steatosis, necrosis, inflammation or fibrosis were observed in the liver specimens from Cs extract-treated mice. , Manabe N; Sugimoto M; Azuma Y; Taketomo N; Yamashita A; Tsuboi H; Tsunoo A; Kinjo N; Nian-Lai H; Miyamoto H , Department of Animal Science, Kyoto University, Japan. ,Jpn J Pharmacol, 70(1):85-8 1996 Jan.

[Genetic divergence of Cordyceps sinensis as estimated by random amplified polymorphic DNA analysis] Random amplified polymorphic DNA(RAPD) has been used in analyzing 13 winter worm, summer grasses (Cordyceps sinensis [Berk.], Sacc.) from 5 areas in Qingzang plateau. For 19 arbitrary primers, each individual showed about 65 RAPD markers. The genetic distances among those 13 winter worm, summer grasses were correlated to their geographic distances. Molecular phylogenetic tree constructed by UPGMA and NJ suggested that 13 winter worm, summer grasses could be divided into 3 clusters: east cluster, north cluster and middle cluster, in consistence with their origins and genetic divergence among different clusters. Furthermore, our results implied that the RAPD markers of winter worm, summer grasses showed a geographic specificity and could be a better genetic marker in studying genetic diversity and phylogeny of winter worm, summer grasses., Chen Y; Wang W; Yang Y; Su B; Zhang Y; Xiong L; He Z; Shu C; Yang D , Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences. , I Chuan Hsueh Pao, 24(5):410-6 1997 Oct..

[Influence of Cordyceps sinensis (Berk.) Sacc. and rat serum containing same medicine on IL-1, IFN and TNF produced by rat Kupffer cells] , The results indicated that the levels of IL-1, IFN, and TNF, especially those of IL-1 and INF, produced by cultured rat kupffer cells were increased in the presence of Cordyceps sinensis (CS) or the drug serum (DS) from rats fed on CS. The experimental result of DS was similar to that of CS. However, the former had a better repeatability and stability., Liu P; Zhu J; Huang Y; Liu C , Liver Diseases Research Center, Shanghai Academy of TCM., Chung Kuo Chung Yao Tsa Chih, 21(6):367-9, 384 1996 Jun

[Effect of Jinshuibao capsule on the immunological function of 36 patients with advanced cancer] Jinshuibao Capsule (JSBC), produced by Jiangxi Jinshuibao pharmaceutical Company Limited, possesses the similar active principles and pharmacological activity with those of Cordyceps sinensis. The effect of JSBC on the immunological function of 36 patients with advanced cancer showed that it could restore cellular immunological function, improve quality of life, but had no significant effect on humoral immunological function. The results suggested that JSBC could be used as adjuvant drug in advanced cancer.,Zhou DH; Lin LZ , First Affiliated Hospital, Guangzhou University of TCM., Chung Kuo Chung Hsi I Chieh Ho Tsa Chih, 15(8):476-8 1995 Aug .

Many other references:

Degliantoni, G. , M. Murphy, M. Kobayashi, M.K. Francis, B.P.erussia and B. Trinchieri, Natural killer (NK) cell-derived hematopoietic colony-inhibiting activity and NK cytotoxic factor. Relationship with tumor necrosis factor and synergism with immune interferon, J. Exp. Med. 162; 1512-1530, 1985

Zhu, X. 1990. Immunosuppressive effect of cultured Cordyceps sinensis on cellular immune response. Chinese Journal of Modern developments in Traditional Medicine 10:485-487, 4540

Dr. Georges Halpern , M.D., "Cordyceps, China's Longevity Secret" , Avery Publishing Group.



Coriolus versicolor Cov-1, "Cloud mushroom"

Ganoderma lucidum

Polyporus frondosus

Hericium erinaceus

Lentinus edodes